Distribution ranges from Southern Chile, the Falkland Islands and South Georgia to the sub-Antarctic islands and seamounts of the Indian Ocean including the Kerguelen, Crozet and Marion Islands, and the Australian Islands of Heard & McDonald.
Toothfish inhabits cold waters between 1°C and 4 °C up to depths of 3,500m. In the Falklands, average fishing depths are around 1,350m, with fishing regularly occurring up to depths of 1,800m.